On December 16, 2008, Shanghai Biochip Co., Ltd. and Biochip Shanghai National Engineering Research Center integrated their system technology platform, commercial service system, high-quality service team and other resources to set up a specialized company dedicated to R&D outsourcing services. Shanghai Bohao Biotechnology Co., Ltd. In the topic of market development of gene chip technology and services, we interviewed Dr. Xiao Huasheng, the current chairman and general manager of Shanghai Bohao.
Core view
First, the market share of gene chips is eroded by high-throughput sequencing, and professional gene chip companies have seen a wave of mergers and acquisitions.
Second, the chip technology is unique and cannot be completely replaced.
Third, microfluidic chip technology in the development of the past decade, still did not bring breakthroughs in the commercial development of gene chips.
Fourth, the future of chip technology is the Lab on a chip.
Fifth, chip technology still has a lot of possibilities in clinical and health applications, and the market prospect is broad.
Question 1: Recently, professional gene chip manufacturers have been mass-produced by giants, including Affymetrix's acquisition by Thermal Fisher, Nimblegen's acquisition by Roche, and Genomic Solutions' acquisition by Digilab. It indicates that the gene chip market is shrinking, or the giants are optimistic about the chip market. And marching in a big way?
A: The wave of mergers and acquisitions of professional gene chip companies is due to the erosion of high-throughput sequencing of the gene chip market. Affymetrix has also been eroded by high-volume sequencing. Although the company has many patents and many US FDA and Chinese CFDA-certified products, these products are generally used in third-party inspections, and the layout of the institute and Hospitals already have related products, and the market growth rate is slow.
There are not many domestic chip companies, mainly based on the state, such as the biochip Shanghai National Engineering Research Center, the biochip Beijing National Engineering Research Center, and the later chip companies such as Beijing Boao and Shanghai Bohao.
Gene chips are much smaller than the market for gene sequencing . The market with gene chips alone as the sole business has relatively weak market competitiveness. Therefore, chip companies are diversified and offer a variety of technology combinations, such as PCR, gene chip, and second-generation sequencing. Technology and peripheral related technologies.
Question 2: Will the gene chip be replaced after the second generation of sequencing?
A: On this topic, we published a review in the 2008 China Science, analyzing the respective advantages of the two technologies, and also have their own application scope in different fields.
As the price of second-generation sequencing has decreased, the application overlap between these two technologies is now getting higher and higher. Gene chip technology is gradually replaced by second-generation sequencing in some fields, but the chip has its own advantages: the technology is relatively mature, the sample processing and data analysis are relatively simple and fast, and there is a big advantage in rapid screening.
The specific application advantages are as follows: there is a great advantage in the rate of gene detection at a fixed site in a large sample, and the reliability of gene detection for low and medium expression kurtosis in gene expression detection is higher, and the speed of research on gene copy number changes Faster, the cost is relatively low. The introduction of microfluidic chip technology can realize detection automation and integration, and the overall efficiency is greatly improved.
Vitamins are a type of trace organic substances that humans and animals must obtain from food in order to maintain normal physiological functions. In terms of physiological functions, vitamins are neither a raw material for tissues nor a substance for supplying energy, but they are an indispensable substance for the body. It has many types and different chemical structures. Most of them are the components of the coenzyme (or prosthetic group) of certain enzymes. They are the indispensable compounds for maintaining the normal growth (growth, health, reproduction and production function) of the body. It plays a catalytic role in the body to promote the synthesis and degradation of major nutrients (proteins, fats, carbohydrates, etc.), thereby controlling metabolism. Vitamins are essentially low-molecular organic compounds. They cannot be synthesized in the body, or the amount synthesized is difficult to meet the needs of the body, so they must be supplied from the outside. The daily requirement of vitamins is very small (usually measured in milligrams or micrograms). They are neither a raw material for body tissues nor a substance for energy supply in the body. However, they do not regulate material metabolism, promote growth and development, and maintain physiological functions.
Vitamin K2 MK-7, Vitamin C, Vitamin E, Vitamin K2, Vitamin H, Vitamin D3
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