Harvard University for the first time finds new secrets behind anti-aging

Aging is a key risk factor for many chronic diseases, but the biological mechanisms behind cellular aging are largely unknown. On December 5, online in a study published in Nature, a team from the Harvard TH Chan School of Public Health first revealed RNA splicing and longevity in the nematode. The relationship between. This study clarifies the biological role of splicing in life and demonstrates that manipulation of specific splicing factors in humans is expected to help promote healthy aging.

Due to advances in public health, life expectancy has increased significantly worldwide in the last century. However, although life expectancy is longer, people may not live healthier, especially in the last decades of life. Age-related diseases such as cancer, heart disease and neurodegenerative diseases are now the main global health burden. This problem may be further exacerbated.

In order for the body (cells) to remain "young," they must maintain proper homeostasis. At the cellular level, this means keeping the flow of biological information, from gene-RNA-protein, to a smooth "run". Previously, a large number of studies have revealed how genetic and protein dysfunction accelerates aging, but little is known about how RNA fractions, including RNA splicing, affect aging.

RNA splicing is a very important biological process in eukaryotic gene expression, enabling a gene to produce multiple proteins. William B. Mair, co-author of the study, said: "Although we know that specific splicing defects can cause disease, we are very interested in the role of RNA splicing in the aging process."

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