According to reports, a recent medical study published by the British journal Nature showed that diabetes increases the risk of cancer.
Hyperglycemia has a negative effect on the level of 5-hydroxymethylcytosine (5hmC), and 5hmC is modified by DNA affected by cancer.
Diabetes is a group of metabolic diseases characterized by high blood sugar. Hyperglycemia is caused by defects in insulin secretion or its biological effects, or both. Hyperglycemia, which persists in diabetes, causes chronic damage and dysfunction of various tissues, especially the eyes, kidneys, heart, blood vessels, and nerves.
According to the data, adult patients with diabetes worldwide have tripled in the past 40 years.
The researchers found that a tumor suppressor gene, TET2, can catalyze the conversion of 5mC to 5hmC, and its reduced activity also reduces the level of 5hmC in cancer patients. AMP-activated protein kinase (AMPK) acts as an important nutrient and energy receptor that phosphorylates TET2 and increases its stability.
In the mouse experiment, the hypoglycemic drug metformin can inhibit tumor growth through the AMPK-TET2 pathway, which brings new ideas to the clinic .
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