Microfluidics help premature infants breathe
October 09, 2018 Source: Chinese Journal of Science
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Respiratory distress syndrome is the second leading cause of neonatal death. In particular, medical workers will try to deliver oxygen to premature babies (about 1/10 of all newborns in the United States) because the lungs are one of the organs that are finally fully developed in the uterus. A new microfluidic innovation brings hope to improve the artificial placenta so that premature babies can develop their lungs properly after birth.
An international team demonstrated the latest technology for building microchannels. This channel provides a more efficient gas exchange between the baby's blood and air. This improved design takes advantage of both sides of the gas exchange membrane and meets nearly one-third of the oxygen requirements of premature infants without an external pumping mechanism. The team used this design to develop a prototype that oxygenated the blood through a membrane. Recently, they reported this achievement in the journal Biomicrofluidics, a subsidiary of the American Physical Union (AIP) Publishing Group.
“The key innovation is the development of large-area microfluidic devices,†said P. Ravi Selvaganapathy, one of the authors. “The reason why it is designed to be microfluidic is that a baby weighing 1 kilogram may only have 100 milliliters of blood. What you need It is a device that uses only 1/10 of the blood volume at a time."
Selvaganapathy and the team rely on the newborn's own heart to pump its equipment. This feature makes future oxygenators particularly suitable for areas that lack sufficient power. After the baby is born, the umbilical cord can be connected to the oxygenator. When the heart beats, it drives blood to flow in the umbilical cord. There, the baby can receive oxygen from the outside air. At the same time, in order to achieve precise control of the device, the researchers constructed a gas exchange membrane with a high surface area to volume ratio. (Zong Hua)
Related paper information: DOI: 10.1063/1.5034791
Journal of Chinese Sciences (2018-10-08 2nd Edition International)
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