British Bibby automatic melting point instrument use and sample preparation precautions

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Liu Gong and Zheng Gong, technical engineers of Guangzhou Special Instrument Technology Co., Ltd. successfully installed the Stuart SMP50 automatic melting point instrument under the British BIBBY in the petrochemical department of Guangzhou in early November 2016. BIBBY's melting point instrument is the world's highest selling melting point instrument. The user gave a high evaluation of the performance of the SMP50.
Next, let's take a look at the use of SMP50 automatic melting point instrument and precautions for sample preparation:
First, note preparation matters:
The automatic melting point instrument is based on the change of the reflected light intensity of the sample in the capillary tube, and the automatic melting point determination is performed. Therefore, the filling and preparation of the sample have certain influence on the accuracy of the measurement result, in order to make the measurement result more Reliable, we should pay attention to the following:
1. Drying of the sample: The powder sample is particularly easy to absorb moisture. Therefore, according to the standard requirements, the sample is taken, placed in a mortar, and placed in a flat weighing bottle, according to the conditions of “dry weight loss” under each variety. dry. If the drug does not check the weight loss of drying, the product with a lower melting point of 135 ° C or higher and not decomposed by heat may be dried at 105 ° C; for a product having a melting point below 135 ° C or thermally decomposed, it may be in a non-oxidized phosphorus dehydrator Dry overnight. If individual varieties are otherwise specified under the variety, they shall be disposed of according to regulations.
2. When loading the sample, if possible, try to load the sample under the illumination of the infrared heating lamp to avoid inhaling moisture.
3. When the capillary is loaded, try to make the sample dense and free of voids. You can throw the capillary repeatedly in the glass tube of 1 meter high for 20-40 times, and the sample filling height can be changed.
4, the capillary sample height, keep 3-5mm high after throwing tight, not too low and not too high
Second, the use of precautions:
1. When cutting the capillary glass tube, cut it in the middle position as much as possible, not a long length, avoiding the short paragraph that cannot be pulled out after being placed in the sample hole position.
2. After the last sample is finished, it takes a certain time for cooling. Please confirm that the temperature of the hot block is lower than the test temperature before proceeding to the next test.
3. Before placing the capillary into the test hole, please check it carefully. There is no crack in the capillary. Make sure that the capillary does not break. It can't be pulled out in the test hole, even the sample leaks in the test hole.
4. Before putting the capillary into the test hole, please wipe the outer surface, do not bring the powder sample into the test hole, avoid the powder accumulation after prolonged use.
Third, the results and judgment
1. The temperature at the time of initial melting, full melting or decomposition mutation in the first method, and the temperature of the melting point in the second method are estimated to be 0.1 ° C, and the phenomenon of mutation or abnormality is recorded. Each test article shall be tested at least three times. If the difference between the three readings is not more than 0.5 ° C and is not at the edge of pass and fail, the average of three times may be taken as the result of the melting point measurement. For example, when the difference of the three readings is 0.5 ° C or more, or when the pass and fail edges are repeated, the measurement may be repeated twice, and the average value of five times plus the correction value of the thermometer is used as the result of the melting point measurement. If necessary, the same drug can be used for the same measurement again, and the results are recorded and compared.
2. The data of the measurement results should be rounded at a repair interval of 0.5, ie 0.1 to 0.2 °C, 0.3 to 0.7 °C to 0.5 °C, 0.8 to 0.9 °C to 1 °C; Data report.
However, when the standard specified melting point range and the effective digits are located in single digits, the data of the measurement results should be rounded at a rounding interval of 1, that is, a single digit adjusted to the standard.
(The results of this paragraph are judged in the Chinese Pharmacopoeia 2010 edition of an Appendix VII C and the second appendix VI C "melting point determination method", China Drug Testing Standards Operational Specification 2010 edition P141 "melting point determination method".

About BT and UK Bibby/Germany Miccra/Germany MC•ART/Germany CAT/Switzerland Gerber Instruments
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Guangzhou Special Instrument Technology Co., Ltd. specializes in general instruments such as laboratory sample preparation such as agitator/dispersive emulsifier, analytical instruments such as melting point/photometer/freezing point instrument, and life science instruments such as PCR. As the first generation of British Bibby in South China, Guangdong, Guangxi, Sichuan, Chongqing, Yunnan, Hainan, Guizhou and Tibet are our services. The company is also the German Miccra, MC•ART, the total generation of Swiss Gerber Instruments in China; also represents German CAT products.

● British BIBBY was established in the 1950s as the largest laboratory scientific instrument manufacturer in the UK with 5 sub-brands: Stuart, Techne, Jenway, Electrothermal, PCRmax. Focus on general laboratory instruments such as sample preparation (eg melting point apparatus, stirrer, mixer, shaker, incubator, dry bath/nitrogen blower, water bath, colony counter, pure water still), molecular biology Research equipment (gene amplification instrument PCR, real-time PCR, hybridization box); spectrophotometer / ultra-micro UV and other analytical instruments, and parallel reaction workstation related products.

● Miccra, Germany, was founded in the last century and is the most professional dispersing emulsifier in Germany and the world. Top-grade dispersing emulsified products range from laboratory instruments, pilot products to industrial equipment. There are hundreds of types of dispersing heads; the fields of application cover chemical, cosmetic, pharmaceutical, food, environmental protection and other fields.

● Gerber Instruments has a history of more than 120 and is a typical representative of the dairy food industry. Its products are freezing point, cream centrifuge, food-specific PH meter, outflow viscometer, etc., which are popular in Europe and other mainland countries.

● Germany MC.ART, known as the provider of small "robots" in the laboratory. Typical representative products include: fully automatic dispersing emulsification system, automatic gripping robot, automatic liquid adding robot, automatic packaging robot, automatic filtering robot and other laboratory automatic control intelligent equipment, as well as laboratory automation customization. Its complementary products include: agitator, circulating water bath, explosion-proof refrigerator with German Cochi, and separatory funnel oscillator.

● Germany CAT was founded in the 1950s and is one of the experts in German sample preparation instruments. Its top-mounted mixers range from hand-held, teaching, to scientific research, and high-viscosity. It is the representative product line of CAT.

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