Release date: 2016-11-07
Recent research explains how metastatic breast cancer cells use bone marrow-derived mesenchymal stem cells (msc) to help them spread to bone tissue. According to an article published in the Journal of Tissue Engineering, a study using a 3 d scaffold model showed that factors from breast tumors can promote maturation of mesenchymal stem cells into bone cells, and mechanical compression of the scaffold further stimulates bone development. . This article will be available for free download on the Organisation Engineering website until December 2, 2016.
Maureen Lynch, Claudia Fischbach and co-authors from Cornell University (Ithaca, NY) and the University of Massachusetts used a mineral-containing 3 d scaffold as an in vitro model to study compounds such as breast tumors and bone microenvironment Whether factors such as internal mechanical stimulation affect the interaction between metastatic tumor cells and bone. Understanding and interfering with these interactions may have clinical implications for patients with nearly 75% of advanced breast cancers with invasive bone metastatic disease.
The article titled "Three-Dimensional Mechanical Load Regulation of Osteogenic Mesenchymal Stem Cells Responding to Soluble Signals from Tumors" describes the composition of the scaffold, the study design, and how to use this model to assess certain bone metastatic breast cancer. Body clues.
"This article reports a very exciting study that uses tissue engineering techniques to control the interaction between tumors and bones, which is of great significance for the development of new therapies," said Antonios G. Mikos, professor and co-editor of the University of Deles.
Source: Noble
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