Solid preparation line:
1. GHL-200 wet mixing granulator
GHL series wet mixing granulator mainly consists of frame and its accessories, material cylinder and cylinder head functional components, mixing paddle and its transmission device, cutter and its transmission device, discharging device, wet particle granulation system, spraying The slurry device, electrical control system, pneumatic control system and other components are composed. Among them, the material cylinder and cylinder head function group, the stirring paddle and its transmission device, the granulating knife and its transmission device, and the granulating device are key mechanical devices. The electrical control system is the core control system of the unit.
The material enters the material tank through manual feeding or vacuum feeding, and is fluidized by mechanical force under the action of the stirring slurry to form a good movement track in the silo to achieve uniform mixing. After the adhesive is injected, the material powder is bridged into fine particles, and under the mechanical force of the stirring paddle, the particles are gradually grown to form the desired particles.
GHL series wet granulator, as an important process equipment for the production of solid preparations in the pharmaceutical industry, realizes mixed granulation of raw and auxiliary materials, or makes software materials. It adopts PLC automatic control system, and the equipment and process meet the requirements of current GMP and national pharmacopoeia.
The main purpose of the product is to mix and granulate powdery loose materials, suitable for:
- powder mixing and granulation in the pharmaceutical process solid preparation production process;
- mixing and granulation of powder raw materials in food engineering;
- Mixing and preparation of loose powder materials in the field of fine chemicals. 
1-1, KZL300 type fast granulator (wet granule)
When the material enters the working chamber of the machine from the hopper, the rotating rotary knife acts on the raw material, and centrifugally forces the particles to the screen plate, and at the same time, the material is cut due to the shearing action between the rotating knife and the screen plate. The whole granules are granulated and discharged through the mesh holes. The fast granulator is ideal for screening a variety of wet or dry granules. The size of the granules depends on the screen type. The fast granulator is unique in structure. It is different from the traditional swaying granulator, but uses blade rotation and frequency conversion. The structure of the speed regulation ensures that the material is not pulverized during the whole granulation, which greatly improves the efficiency, so that the uniformity of the particles is increased, the qualified particles are increased, and the remaining bad particles are reduced to less.
All the parts in contact with the material and the outer seal of the equipment are made of stainless steel, the inner mirror is polished, the outside is bright and matt, there is no metal friction between the blade and the screen, and the lower mouth and the host are rotated by silicone rubber. The post-sealing is convenient for folding and has the production standard in line with the pharmaceutical industry.
The fast granulator can simply replace the stator blades and screens for quick cleaning.
To achieve the desired results, the appropriate speed and parameters, the centrifugal force of the material, ie the speed of the blade, the hole shape and specifications of the mesh must be selected.
1-2, ZKS-5 vacuum feeder
1-3. The pressure refining system tank is a pressure-bearing component. After the quantitative binder is added, the binder is sprayed into the cylinder through the nozzle under the pressure of the compressed air. The cylinder block is made of 304 stainless steel;
Adhesive adhesive is added: the adhesive in the pressure tank is injected into the cylinder through the nozzle through compressed air. For low-viscosity adhesive, the injection method can achieve perfect granulation effect; after the adhesive preparation is completed Manually add the pressure tank.
Second, FL-100 boiling granulation dryer (explosion-proof type)
The material is moved upward from the hopper to the diffusion chamber by the thrust of the air flow. Since the diameter of the diffusion chamber is large, the air flow rate is low, and the material itself gravity falls against the thrust of the air flow, thereby reciprocating to form a fluidized state. However, the fluidization state is irregular and is not strictly controlled. This is different from the bottom spray and the tangential spray.
The liquid medium is transported into the system through the atomization system, and is atomized into tiny droplets from the top to bottom, in the opposite direction to the direction of movement of the material. Through the liquid bridge built by the surface tension of the liquid medium, the powder materials are bonded together to form a volume that is continuously enlarged, and the Zui finally forms particles of a certain size.
Third, HTD-400 single-arm mixer This machine is composed of machine base, rotary body, drive system, lifting system, braking system and control system. When working, push the mixing hopper into the rotary body and press the “confirm†button on the touch screen to automatically raise the mixing hopper into position and automatically clamp it. After the pressure sensor obtains the clamping signal, the drive system works and mixes according to the set time and speed; after the set parameters are reached, the rotary body can automatically stop vertically, and the brake system works, the mixing ends; then the system works. The mixing hopper in the swing body is lowered into position, automatically stopped, and the process data is printed. Pull the mixing hopper out to the next step.
HTD series automatic lifting hopper mixer is a common mixing equipment used in the production of solid preparations in pharmaceutical factories in the world. It has mixed hopper mouth to move away or clean, easy to use and flexible, good mixing effect, convenient for feeding and discharging, mixing The time and mixing speed can be determined by different drugs, and can be sandwiched by various specifications and different volume of mixing hoppers. It is very popular among pharmaceutical companies and is the ideal mixing equipment for Zui.
Fourth, FLD-400 square turnover hopper FLD mixing hopper in the fixed preparation production process, mainly with FZD series automatic hopper lifting mixer, FTD series column hopper mixer, FLD series single arm hopper mixer used. And as a turnover container, the materials can be used in different uses in the same container to achieve frequent processes such as no material transfer or no material feeding, effectively preventing dust and cross-contamination. Full compliance with GMP requirements for pharmaceutical production.
V. 30B-X Universal Crusher This series of high-speed stainless steel pulverizers are all integrated, with solid structure and stable operation. The pulverizer is made of stainless steel. The internal stainless steel pulverizer is made of stainless steel except that the casing is made of stainless steel. It has good corrosion resistance and can ensure the purity of the pulverized materials.
This series of crusher is mainly composed of several main components such as base, casing, main shaft, movable plate, fixed plate, sieve and hopper. The movable plate is fixed on the main shaft, and the fixed plate is mounted on the front cover. After the motor is started, the movable plate is activated. Follow the spindle together for high-speed rotary motion. This model can achieve continuous discharge and no dust flying.
Biochemical industry
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