How to choose intracellular amplifiers and extracellular amplifiers?
The expression of cell membrane ion channels is the basis of cell electrical activity. In cell electrophysiological studies, ion channel current values ​​are in the range of pA to nA. In order to collect, process and analyze these weak signals, cell signal amplifiers It has become an indispensable tool in the study of cell electrophysiology. What is the difference between intracellular signaling and extracellular signaling? How to choose intracellular amplifiers and extracellular amplifiers? What is special about WPI's cell amplifiers? Mr. Cliff, President of WPI, will answer you one by one.
January 14, 2015, Mr. electrophysiology as a senior expert Cliff had a wonderful and professional training system for the WPI team in China. From the interesting lemon "electric shock" experiment, to the membrane potential phenomenon accompanying cell life activities, to the principle and application of intracellular amplifiers and extracellular amplifiers, we all feel the charm of life science. Let us explore and share the mysteries with you now.
What are the characteristics of intracellular signal conduction? What characteristics should an intracellular amplifier have ?
The intracellular amplifier records and amplifies the electrical activity in a single cell. Therefore, the electrode needs to be placed in the cell, and the electrolyte solution should be filled in the glass electrode; since the potential change in the cell is obvious, the voltage signal is relatively large. potential change speed quickly, the time variation of only about 50 μ s, so the magnification intracellular amplifier is relatively small, typically × 1; intracellular amplifier DC mode typically requires a ground electrode; although now more Many people are using patch-clamp technology, but WPI intracellular amplifiers still have a place for their economical features, including Duo773 , FD223a , and Electro 705, which are still the first choice for intracellular signal amplification in plant and animal electrophysiology studies.
Application areas of intracellular amplifiers:
â— Recording of action potentials in nerve cells
â— Recording of action potentials in cardiac cells
â— Recording of action potentials in muscle cells
What are the characteristics of extracellular signal transmission? What characteristics should an extracellular amplifier have?
Extracellular amplifiers are a combination of many cell potential responses, so their electrodes need to be placed outside the cell, even outside the tissue. For example, our common electrocardiogram, electroencephalogram, electromyogram, and intestinal electrogram are all extracellular amplifiers. The electrodes are typically metal electrodes. Because the farther away from the cell, the smaller the signal, the smaller the extracellular potential change and the smaller the voltage signal, which requires a very large amplification of the extracellular amplifier; the extracellular amplifier is more likely to be used in AC mode. , but DC mode can also be used.
At present, WPI 's DAM series amplifiers have become the industry standard for extracellular electrical signal amplification in the global market. Why?
If you ask customers who have used WPI extracellular amplifiers, he will tell you two important reasons: 1 DAM series amplifiers have the best anti-interference and anti-noise effects, and the signals are very clear; 2 DAM series amplifiers have a very wide recording range. Broad. This is mainly because these battery-powered bioamps have a convenient active preamplifier that allows the user to reduce the distance between the sample and the instrument to reduce the length of the wire that can cause noise. Each amplifier is equipped with an optional high-pass or low-pass filter and has potential control to counteract the drift of the coupling voltage during recording.
Application areas of extracellular amplifiers:
â— ECG research
â— EMG research
â— EEG research
â— Retinal potential study
â— Composite action potential recording
â— Unit action potential record
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