Release date: 2014-12-15
Paul Allen became rich by creating Microsoft with Bill Gates and was hailed as "a man who has more money than God."
On Monday, December 8, 2014, Paul Allen donated $100 million to the Allen Institute for Cell Science.
The newly formed Allen Cell Science Institute is similar to the Brain Science Institute in Seattle, Washington, which was co-financed by Allen and Microsoft in 2003. So far, brain science research institutes have spent hundreds of millions of dollars to create a series of "brain map models" to determine whether genes at specific loci are active or to study the connections between distant neuronal cells, and these models have A great interest of neurobiologists.
The first round of the "Local" laboratory: building a "cell observatory"
As the first project of the new laboratory, the Allen Institute of Cell Sciences will establish a structure similar to the "cell observatory". As we all know, the Observatory is an institution specializing in astronomical observations and astronomical research. Each observatory has some instruments for observing the sky like astronomical telescopes. It is a good place to watch the stars.
The "cell observatory" is a platform for observing the internal structure of cells. Through the "cell observatory", scientists observe how certain parts of cells (such as ribosomes, microtubules and mitochondria) work, and how they are over time. Mutual influence and operation.
The director of the new institute closed the original laboratory and wholeheartedly embraced "Allen" thighs
Rick Horwitz, the newly appointed director of the Allen Cell Science Institute, said he closed his cell biology lab at the University of Charlottesville, Virginia, which happens to be in Seattle. The new lab will focus more on the many activities within the cell as a whole. There are now about 70 researchers joining the “Cell Observatory†project. It’s not for your own benefit, but for the overall goal. “This plan is more like the previous Manhattan plan,†Rick Horwitz said.
The research task in the cell field is very difficult to plan to construct a variety of different cell lines.
It is understood that Paul Allen's wealth is now ranked 27th in the world. However, scientists feel that positioning every detail of every kind of cell is still a difficult task. "The problem we are facing now is that this thing may be beyond our control. Because it may be a very, very large project," Horwitz said. "What we need to do now is to make an informed decision as much as possible."
After this year's meeting with top cell biologists, we have made some decisions. The institute will study human induced pluripotent stem cells (an artificially induced embryonic stem cell-like cell) because it can be differentiated into two types of cells in the laboratory: heart muscle cells called cardiomyocytes, and the junctional body cavity. Epithelial cells. These two tissues were chosen because they are more associated with the disease - myocardial failure in heart disease, and most cancers occur in epithelial tissue - and because they can be easily cultured in the laboratory.
The Institute plans to construct a number of different cell lines and determine how different components of the cell respond to stimuli such as infection or exposure to drugs. These data will lead to the construction of computer models designed to predict the functioning of cells under different conditions. Then the data will be placed online for everyone to use. The institute will also allocate its cell lines to facilitate research by other scientists in this area.
Pressure Mountain: Research results must be released within five years, otherwise no funding will be provided
Allan Jones, director of the Institute of Brain Science, established in 2003, said: Allen's $100 million plan covers the first five years, after which Allen will review the achievements of the observation experiment and decide whether to continue funding. Although the Institute of Brain Science only got 100 million US dollars at the beginning, after the effort, it received another 400 million yuan in follow-up funds. Therefore, the success of the cell research institute will mainly measure the research results. After all, the Brain Science Program of the Institute of Brain Science has produced dozens of articles and extremely extensive biological influences. Allan Jones also said: "In order to continue to fund, you need to achieve a high-quality result that everyone believes and trusts."
Sandra Schmid, a cell biologist at the Southern Medical Center at the University of Texas at Dallas, said: As with many neurobiological studies, the Allen Cell Research Program will run like the Allen Brain Research Program, "Cells The Observatory will be the starting project for cell biologists.
But systemic biologist Ruedi Aebersold (also an enthusiast of the program) at the Federal Institute of Technology in Zurich, Switzerland, said that the final evaluation of the Institute's cell biology efforts would take time. Some people may question how we will work to accelerate our research within five years.
Trey Ideker, a systems biologist at the University of California, San Diego, said predicting cell behavior is an exciting and ambitious project. The fear is that they are not getting attention and that the current director Rick's mission is to tell the world. What the institute is planning to do.
Source: biodiscover
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