Quick Detail:
Product Name:Telmisartan
CAS: 144701-48-4
MF: C33H30N4O2
MW: 514.63
Mp: 261-263°C
Density: 1.16
Storage temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Solubility DMSO: >5 mg/mL at 60 °C
Water Solubility insoluble
Chemical Properties White or off white crystalline powder
Usage An angiotensin II receptor antagonist
Purity: 99%
Usage: API
Package: 1KG foil bag; 25Kg drum
Description:
Telmisartan is contraindicated during pregnancy. Like other drugs affecting the renin-angiotensin system (RAS), telmisartan can causebirth defects, stillbirths, and neonatal deaths. It is not known whether the drug passes into the breast milk. Also it is contraindicated in bilateral renal artery stenosis in which it can cause renal failure.
Applications:
Telmisartan is a new antihypertensive drugs, a specific angiotensin II receptor (AT1 type) antagonist.Telmisartan alternative angiotensin II receptor binding with high affinity AT1 receptor subtype.Telmisartan AT1 receptor sites in any part of agonist effects of telmisartan in combination with selective AT1 receptors, the binding lasting effect.Buck stability does not cause coughing
Specification:
| Items | Specification | Results |
| Appearance | White or slightly yellowish crystalline powder | White crystalline powder |
| Solubility | Should meet the requirement | Conforms |
| IR Identification | Should correspond to the RS Infrared Absorption | Correspond to the reference substance |
| Appearance of solution | Should meet the requirement | Conforms |
| Loss on drying | ≤0.5% | 0.20% |
| Sulphated ash | ≤0.1% | Conforms |
| Melting point | 261 ºC -263 ºC | 261.1 ºC -262.2 ºC |
| Particle size | 90% Less than 200um | Conforms |
| Assay | 99.0%~101.0% | 99.9% |
| Conclusion | It conforms to European Pharmacopoeia 7.0 | |
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