Release date: 2016-06-13
The research team of the Keio University of Medicine in Japan recently succeeded in using human versatile stem cells (iPS cells) to produce high-purity cardiomyocytes that hardly have to worry about cancer. The cardiomyocytes can be transplanted directly into the heart to expect effective recovery of cardiac function. The research team will conduct clinical research on patients with severe heart failure.
Usually, some undifferentiated cells that have not fully grown remain in the iPS cell culture process, posing a risk of canceration. Previously, the research team of Keio University's medical department succeeded in producing high-purity cardiomyocytes by replacing the main energy source of glucose in the culture medium with lactic acid, a unique energy source of the myocardium. This study found that glutamate, like glucose, is also an energy source for human cells. When human iPS cells are cultured, glutamic acid and glucose are removed together, and high-purity and high-safety cardiomyocytes having an undifferentiated cell residual rate of less than 0.001% can be produced.
The research was funded by national research institutions such as the Japan Medical Research and Development Agency (AMED) and the Japan Science and Technology Agency (JST). These two institutions have jointly launched the "Recycling Medicine Practical Highway" program and the "Removal of the Research and Development System Bottlenecks that Restrict the Practical Research of Health Research" to support the practical research of regenerative medicine.
With the strong support of the government, research on myocardial regenerative medicine in various research institutions in Japan has progressed rapidly. Earlier, Osaka University has announced the successful production of iPS flaky cardiomyocytes, ready for clinical studies to transplant flaky cardiomyocytes into the heart.
Source: China Medical Network
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