Recently, an international research team led by Chinese researchers has completed the largest Chinese genome sequencing and analysis to date. The research project has collected more than 140,000 Chinese pregnant women with “non-invasive prenatal genetic testing†technology for two years. Part of the genome sample, the final research results published in the "Cell" magazine.
Researchers at the project said that the study's sequencing targets accounted for about one-tenth of China's total population, and it covered 36 ethnic minorities in addition to the Han. The study enabled genome-wide association analysis of multiple phenotypes and constructed a Chinese population gene frequency database (CMDB) containing approximately 9 million polymorphic loci, including approximately 200,000 newly discovered polymorphic loci.
The study found that a genetic variation called NRG is related to the probability of twins in pregnant women. At the same time, a genetic variant is associated with a high concentration of herpesvirus 6 in the blood of pregnant women, which is a common cause of "rose rash" in infants. .
The study also showed that the Chinese have genetic variants common to some Indians, Southeast Asians, and Europeans along the ancient Silk Road.
It is worth noting that this study also found a unique distribution of viral DNA in the Chinese genome.
Xu Xun, the author of the research article and dean of the Huada Life Science Research Institute, said that the above research results have filled many gaps in the field of large-scale Chinese genomics research, revealing a series of unique genetic characteristics of the Chinese population, which will help promote The development of precision medicine in China accelerates the application of genetic technology in birth defects, cancer, and infection.
Xu Xun said that although "non-invasive prenatal genetic testing" is low-throughput sequencing, the base number of sequencing targets is large, so the above data will still help to have a global understanding of the genetic structure of the Chinese population. Rasmus Nelson, a co-author of the paper and a professor of integrated biology at the University of California, Berkeley, said that it is great to get such a large sample size and find out the relationship between genetic variation and human characteristics.
At the same time, this is the first time that top international academic journals have agreed that the data used in the articles in their publications need only be stored in the Shenzhen National Gene Bank, without having to back up to overseas databases. According to Yangguang.com, this means that international academic journals fully respect and recognize China's resource protection laws and regulations. It also means that China has the ability and strength to manage and protect China's important genetic resources. It is very important for China's genetic data autonomy. Significance.
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