Author: Wang Xingwang Date: 2018-07-24
Myocardium is one of the worst regenerative tissues in the body. Cardiomyocyte regeneration has always been a scientific problem that scientists are trying to overcome. A new study from the University of Oxford in the United Kingdom says scientists have found ways to regenerate their heart muscles, prevent heart failure and improve heart disease.
Professor Paul Nelli, a researcher at the University of Oxford, and his team injected a protein called "VEGF-C" into a heart attack mouse. The area of ​​heart damage was significantly reduced and the heart pumping capacity was almost normal. In contrast, mice that did not receive this protein injection lost nearly half of their heart function after a heart attack. Due to the large area of ​​myocardial damage, immune cells that accumulate in the damaged area do not work well, resulting in myocardial scarring, impairing the ability of the heart to pump blood, resulting in a change in heart shape.
Professor Nelly said that VEGF-C protein can promote lymphangiogenesis, prevent myocardial damage and prevent inflammation. Because after a heart attack, immune cells clear dead or dead cells, but this can exacerbate inflammation and easily lead to heart failure. The researchers said that the new protein injection therapy is expected to be put into clinical use within five years. Based on this important study, healing heart failure will also be just around the corner.
Source: Life Times
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