The high-precision filling of aerosol requires superb technology and rich experience. The accuracy of aerosol filling is directly related to the quality of aerosol, especially for products with special requirements, such as pharmaceutical aerosols. . Therefore, filling accuracy is one of the parameters that must be controlled during aerosol production. Mastering the skills of aerosol filling can ensure the accuracy of aerosol filling. The filling of aerosol is a technology and an art.
1. Aerosol filling equipment should have a regular maintenance plan and a daily inspection plan. The routine maintenance and inspection of the aerosol filling machine should include at least the aerosol filling machine seals, control components, pneumatic circuits, and related knowledge devices to ensure that the aerosol filling machine is in good working condition.
2, the pressure control during the filling process, which includes two aspects, one is the working pressure of the aerosol filling machine and its booster pump, and the other is the pressure of the propellant delivered to the aerosol filling machine. Under normal circumstances, the working pressure of the pharmaceutical booster pump is stable, and the pressure of the propellant delivered to the aerosol filling machine can be kept stable. Ensuring the stability of these two pressures is a prerequisite for ensuring aerosol filling accuracy. At the same time, these two pressures must be set within the appropriate working range during the filling process to ensure that the propellant is continuously transported and filled in the liquefied state and that the proper filling pressure is ensured.
3. Ensure that there are no gases that are not easily liquefied in the dosing chamber and filling head of the aerosol filling machine. If so, it must be drained to ensure the accuracy of the aerosol filling. When using the two-step aerosol filling, it is also possible to discharge the gas which is not easily compressed in the metering chamber and the filling head by means of pre-filling due to the separate propellant filling; for the one-step filling, due to the medicine The liquid is always in a circulating state, so that the dosing chamber and the gas that is not easily liquefied in the filling head can be discharged by circulating the chemical solution.
4. Choose the right filling head. Different aerosol valves used in the production process may have different filling parameters and parameters, such as the sealing position between the filling head and the valve, the lowering stroke of the valve stem, etc., so different valves must The corresponding filling head can be used to ensure the correct filling of the aerosol. At the same time, it is necessary to ensure the correct sealing between the filling head and the valve during filling, and adjust the height of the filling head appropriately to ensure sufficient The compressive force is applied to the seal between the filling head and the valve to ensure sealing and prevent leakage during filling.
5. The temperature of the propellant. During the filling process, the temperature of the propellant will affect the accuracy of the filling. The temperature of the propellant will affect the density of the propellant, thus affecting the accuracy of the filling. Under normal circumstances, for example, for HFA 134a, when the temperature difference is 5 ° C, the theoretical difference in the filling of the propellant can reach about 1%.
In short, the precise filling of aerosol requires both the corresponding technology and an art. It requires constant exploration and accumulation of experience, and the combination of technology and art can achieve high quality aerosol.
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