The British "Nature·Biomedical Engineering" magazine recently published a new online report saying that American scientists have developed a new device similar to the "microscopic tube maze", which can detect sepsis quickly with a single drop of blood. This method of detection is fast, inexpensive, and accurate, making it easy to monitor patients at risk for sepsis.
Sepsis is a fatal disease. When pathogenic bacteria or conditional pathogens invade the blood circulation to grow and reproduce, the patient's body will respond extremely to serious infections, causing damage to tissues and organs. However, according to statistics, about 30% of patients will be misdiagnosed because the detection methods used by humans at this stage are poorly specific and slow, and it takes several days to produce results, which leads doctors to prescribe unnecessary antibiotics. Lead to the spread of antibiotic-resistant strains.
In view of this, Daniel Elimia, a scientist at the Massachusetts General Hospital, and his colleagues designed a new detection device. They dropped a drop of blood into a "maze" device made up of microscopic tubes and then correlated the movement of neutrophils in the maze with the severity of sepsis through a machine learning algorithm. Neutrophils have chemotaxis, phagocytosis and bactericidal action, and are in the first line of the body against microbial pathogen invasion, just like the "first responder" of the immune system. Through its special association with sepsis, the device can calculate a "sepsis score."
The researchers showed that the test took only a few hours, and in a double-blind observational study of 42 patients, healthy individuals were distinguished from those with sepsis based on sepsis scores, with sensitivity and specificity of more than 95%.
Currently, the test method needs to be validated through a larger, more diverse patient group, but the researchers say that this new outcome still has the potential to improve the survival rate of patients at high risk for sepsis, while reducing the excessive use of antibiotics. .
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Improvements in microscopy make it harder for cells to escape the doctor's eye. It can be expected that there will be more fine machine eyes in the future, which will help us to see and understand. By then, whether it is a mysterious pathogen, a violent immune cell, or a sputum tumor cell, it will be controlled in time without accidentally injuring the healthy body. Good and big.
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