"Magnetic Knife" can kill brain tumor cells

:2017-08-10

Professor Cheng Yu, a member of the Oriental Hospital of Tongji University School of Medicine, cooperated with Professor Gustavo of Madrid University of Technology in Spain to successfully kill mouse brain tumor cells using a “magnetic knife”. Related research papers were published in the internationally renowned journal "Therapeutic Diagnostics".

In the research, Cheng Yu proposed a new concept of "magnetic knife", that is, magnetic nanoparticles produced mechanical force with a similar "rotary stirring" function under the action of low-intensity magnetic field. The use of this mechanical force can destroy the tumor cells and achieve the same mechanical force as the scalpel.

Cheng Yu introduced that the research team initially tried to use a plurality of nano-magnetic particles for preparation, but the magnetic particles have no obvious damage to tumor cells. After increasing the magnetic saturation intensity of each nano-magnetic particle, the magic phenomenon occurs: magnetic nanoparticles like a piece of "square building block" injected into the cell have strong penetrating power and do not run around, basically gathering in The cells are shaped like mango-like lysosomes and reassembled in the direction of their own magnetic field lines. The orderly arrangement is achieved. Under the guidance of the magnetic field inside the magnetic nanomaterials and the space limitation of lysosomes, they form a shape similar to rice grains. Size micron-sized mango-shaped assemblies, and then these assemblies are placed in a low-intensity magnetic field, the magnetic nano-materials in the "mango" body will start a new round of reorganization, and again follow the direction of the magnetic field lines of the external low-intensity magnetic field, Reconstituted into a shuttle-shaped assembly of rice grain size. After two deformations, the fusiform "magnetic knife" was assembled successfully. The fusiform "magnetic knife" also requires two steps to attack the cells. First, the lysosomal membrane shaped like a mango in the cell is attacked. After the lysosomal membrane is attacked and defeated, the cells are attacked. Under the double attack of "magnetic knife", the cell eventually went to death.

Cheng Yu said that this nano-material known for its small size, coupled with the magnetic "wings", makes magnetron nano (micro) meters technology have great application prospects in biomedicine. At the same time, the low-intensity magnetic field has no harm to human cells and tissues and high penetrability, which provides a great possibility for minimally invasive surgery, cell manipulation and analysis, and targeted therapy. If the progress is smooth, the "Magnetic Knife" synthesizing device will be developed successfully after half a year to one year. After various audits, it will be introduced to the clinic as a new type of cancer treatment.

Source: Health News

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