Release date: 2018-03-26
Although prostate cancer has been clinically well controlled at some stages of cancer development, once cancer cells invade and metastasize to other distant organs, the patient's survival is seriously threatened. Therefore, an in-depth understanding of the pathogenesis of cancer cell invasion is necessary to develop effective targeted therapies to prevent cancer cell metastasis.
Recent researchers from the Commonwealth University of Virginia have predicted that melanoma differentiation-associated gene 9 (syntenin or SDCBP) is associated with prostate cancer progression based on bioinformatics data analysis, and further corroborates the correlation by sample analysis and cytology experiments. The relevant research results were published in the international academic journal Cancer Research.
In this study, the researchers used Gleason graded prostate cancer patient tissue samples, normal prostate tissue, prostate cancer cell lines (with different tumorigenic and metastatic properties), mda-9/syntenin variant cell lines (loss of function) And functional access) and cells that stably knocked out MDA-9/syntenin with CRSPR/Cas9 confirmed the dependence of prostate cancer invasion on MDA-9/syntenin and the correlation between the two.
The researchers found that MDA-9/syntenin interacts with the insulin-like growth factor 1 receptor (IGF-1R) after treatment with insulin-like growth factor binding protein 2 (IGFBP-2), which regulates downstream signaling processes and promotes STAT3 Phosphorylation. This activation enhances the expression of MMP-2 and MMP-9, both of which have a positive regulatory effect on cancer invasion. In addition, MDA-9/syntenin also mediates upregulation of pro-angiogenic factors, including IGFBP-2, IL-6, IL-8 and VEGF-A, which promote the migration of prostate cancer cells.
Overall, this result suggests that MDA-9/syntenin is a positive regulator of prostate cancer metastasis, targeting this molecule may develop potential therapeutic approaches to inhibit prostate cancer invasion and metastasis, and may also have therapeutic effects on other cancers. .
Original source:
Swadesh K Das, et al. The MDA-9/Syntenin/IGF-1R/STAT3 axis directs prostate cancer invasion. Cancer Research, DOI: 10.1158/0008-5472.CAN-17-2992
Source: Bio Valley
Suture Needle,Chromic Catgut Suture,Chromic Suture,Medical Disposable Suture
Surgimed Medical Supplies Co.,Ltd , https://www.surgimedcn.com