Obsessive-compulsive disorder further increases the risk of death

In a large-scale prospective cohort study published online January 27th in the Journal of the American Medical Association, Psychiatry, researchers from institutions such as Aarhus University in Denmark used data from the Danish Longitudinal Registration System to explore The topic of whether or not the mortality rate of patients with obsessive-compulsive disorder (OCD) increases.

This national study included a total of 3 million individuals born between 1955 and 2006. The follow-up period was from January 1, 2002 to December 31, 2011, totaling 30 million person-years. In the meantime, a total of 27,236 individuals died. The investigators analyzed the data in June 2015, which was mainly attributed to adjustment of the calendar year, age, gender, age of parents, place of birth, and comorbidity of the body, mortality rate ratios (MRRs), and obsessive-compulsive disorder. Patients with OCD were compared with non-patients.

A total of 10,155 individuals diagnosed with OCD were included in the study, including 5935 females and 4,220 males, with a mean age (SD) of 29.1 (11.3) years, of which 110 (1.1%) were on average during the 9.7-year follow-up period. death.

"Compared" OCD with comorbid Depression/Anxiety Disorder/Substance Use Disorder in OCD Patients: Mortality Comparison (Meier SM, et al. 2016)

After adjusting for sociodemographic factors and somatic comorbidities, the all-cause MRR of patients with OCD was 2.00 (95% CI, 1.65-2.40), suggesting that the risk of premature death was two times that of the general population;

After adjustment of the above factors, the natural MRR (1.68 [95% CI, 1.31-2.12] and unnatural death risk (2.61 [95% CI, 1.91-3.47]) were significantly higher than those in the general population;

40% of OCD patients died of unnatural causes, among which the risk of death due to suicide (MRR 3.02) and accident (2.09) was significantly higher than that of the general population;

Compared with non-diseased siblings, all-cause death (MRR 1.87), natural death (1.91), and unnatural death (3.81) MRRs of OCD patients were similar to those of the general population, and had statistical Significance, suggesting that the risk of early death of OCD may not be affected by familial confounding factors;

In patients with comorbid anxiety disorders, depression, and substance abusers, OCD is still significantly associated with increased mortality (MRR, 1.88 [95% CI, 1.27-2.67]); and once these factors are comorbid, OCD patients are at risk of death. Will be further increased, such as the diagnosis of comorbid substance abuse disorders, the risk of premature death of OCD patients rose to 6.32 times the general population, the risk of unnatural death rose to 15.29 times the general population.

Researchers point out that OCD is associated with a significant increase in premature death risk. Although comorbid depression, anxiety disorders, and substance use disorders can further significantly increase this risk, even if these factors are adjusted and somatic comorbidity, the risk of death from OCD is still statistically significant. The above findings provide new information for the long-term outcome of OCD and further emphasize the importance of targeted treatment and suicide prevention efforts.