Release date: 2013-07-19
American scientists use human induced pluripotent stem cells (iPS cells) to create artificial blood vessels that survive 280 days in experimental mice. The findings, published in the latest issue of the Proceedings of the National Academy of Sciences, helped develop new forms of heart disease and diabetes.
The Massachusetts General Hospital research team used human iPS cells to create vascular precursor cells, which were then transplanted to the surface of the experimental mouse brain. Two weeks later, the precursor cells became functional blood vessels and continued to work for 280 days. During this time, the performance of these artificial blood vessels was the same as that of the natural blood vessels of the experimental rats.
Scientists believe that the ability to repair or nurture new blood vessels is expected to be the basis for new treatments for heart disease and diabetes.
Previously, scientists used the same method to make artificial blood vessels, but they could not guarantee long-term effects after transplanting into animals. In addition, Ricky Kingn, the lead author of the research paper and the Massachusetts General Hospital, said that the same cells can be transplanted under the skin to create blood vessels, but this blood vessel has a shorter life span and requires precursor cells. It is 4 times more. Relatively speaking, the new method is more convenient and faster.
Jin En believes that stem cell technology has brought great vitality to the field of cell-based regenerative medicine, but the use of iPS cells to create functional cells still faces many challenges.
Source: Kexun
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