Release date: 2017-12-07
With the development of technology, researchers can now use the new technology to synthesize filamentous materials with mechanical properties similar to those of real spider silk. This material may be expected to be used to treat various types of diseases such as cancer. Recently, a publication In a study published in the international journal Advanced Materials, researchers from Stockholm developed a new method to create bioactive spider silk structures.
Image source: The Royal Institute of Technology
Because of its good strength and elasticity, spider silk has attracted the attention of scientists due to its potential use in medicine. Researchers hope to use spider silk as a scaffold for tissue repair, transport drugs, biomarkers or antibacterial coatings. Layer and so on. But finding a satisfactory way to synthesize proteins that mimic spider silk seems to be very elusive for scientists. Researcher Hedhammar said that we are trying to use the microfluidic, wet spinning and electrospinning technologies to start the process of simulating spinning, many of which are very difficult to design and require some harsh chemicals (such as methanol) to make the wire It is insoluble in water after formation and avoids the loss of its biological activity.
Based on this, the researchers used a newly developed biochemical technology that uses micro image surfaces to concentrate proteins to form organic nanowires or coating structures. Like a very small brush, the researchers used a micro-silica column on the surface that was somewhat hydrophobic; the researchers then designed two types of filamentous proteins, one of which is highly antibody-sensitive. Affinity, the other has cell binding properties.
After removing the soluble filamentous protein droplets on top of the micro silicon column, the researchers completed three different forms of synthetic filamentous structures, nanowires (which can be used as cancer therapies) and local coatings (local coatings, For the detection of biomarkers) and silk sheets, which can be used as cell growth scaffolds. For example, in order to develop nanowires, the researchers placed droplets on the surface structure of this tiny image and then dragged the droplets, leaving a lot of silk material on the pillars.
Similarly, in order to develop a silk structure, the researchers placed the droplets on top of the surface of the microimage, and the stability of the resulting silk structure was detected by immersing it in water and cell culture medium; the researchers said, The new silk cotton structure has a certain integrity, and it does not show any signs of dissolution, which confirms that a special protein can be successfully converted into a stable filamentous structure. (Bio Valley Bioon.com)
Original source:
Linnea Gustafsson, Ronnie Jansson, My Hedhammar, et al. Structuring of Functional Spider Silk Wires, Coatings, and Sheets by Self-Assembly on Superhydrophobic Pillar Surfaces. Advanced Materials, December 2017 DOI: 10.1002/adma.201704325
Source: Bio Valley
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