US researchers said on the 19th that they have found a way to convert “bad†fats into “good†fats, which may make it easier for people to lose weight.
The human body has two kinds of adipose tissue, white fat and brown fat. White fat is mainly used for storing heat, while brown fat is responsible for consuming energy to generate heat. In layman's terms, white fat is the “bad fat†that causes obesity, and brown fat is “good fat†that can lose weight. If you can convert white fat into brown fat, obesity can be greatly improved.
Researchers at the Washington University School of Medicine in St. Louis reported in a new issue of the American Cell Report that mouse experiments have shown that inhibiting the activity of a protein called PexRAP in white fat causes the fat to move from white fat to white fat. The conversion of beige fat to brown fat causes the fat cells to heat up, consuming calories, and making the mice thin.
Researchers said that beige fat is an intermediate between white fat and brown fat, and can switch between the two, but its function is more similar to brown fat and can prevent obesity.
"Our goal is to find a way to treat or prevent obesity," said the first author of the paper, assistant professor Irfan Lowdy, in a statement. "Our research shows that by inhibiting a protein in white fat, Active, can convert 'bad' fat into a fat that prevents obesity."
Lodi said that their work means that drug developers may now have a new goal that makes it easier for people to lose weight, but the challenge is to find a safe way to inhibit the activity of PexRAP protein in human white fat without causing the body to overheat or fever.
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