Solid equipment refers to all equipment produced in the solid preparation workshop. What equipment is there? Today, Zhongnan Xiaobian explained in detail to you: mainly divided into six categories.
First: crushing equipment:
1. Grinder: Using the high-speed relative motion between the movable toothed disc and the fixed toothed disc, the object is crushed and crushed by the combined effects of gear impact, friction and impact between materials. Currently there are 20B, 30B, 40B
2, high-speed rotary impact pulverizer: according to the different mechanical structure, it can be simply divided into hammer type, lock holding type, rotary disc type, axial flow type, etc.; according to the difference of rotation can be divided into vertical, Horizontal. The high-speed rotating wheel disc is used to violently strike or impact the material, so that high-frequency mutual impact, shearing and the like are generated between the materials to achieve the purpose of crushing.
3. Ball mill: According to its movement mode, it can be divided into ordinary horizontal ball mill, horizontal reverse rotary ball mill, vibrating ball mill, new high-fine ball mill and so on. The ball mill has the characteristics of good sealing, dust is not easy to fly, etc. It has strong adaptability to materials, continuous production, large production capacity, and easy to adjust the hungry fineness of the grinding products. It can be dry or wet, and can be dried. Simultaneously combined with grinding.
Second, the mixing equipment:
The mixing equipment includes a two-dimensional motion mixer, a multi-directional motion mixer, a square cone mixer, a hopper mixer, a CH-slot mixer, a fast mixer, a three-dimensional mixer, and the like.
Third, granulation equipment:
1. High-speed stirring granulator: The raw materials, auxiliary materials and adhesives are added into a container, and the mixing and granulation are quickly completed by adjusting the stirring, shearing and compaction of the rotating agitator.
2. Boiling granulating dryer or one-step granulation: mixing, granulating and drying are completed in one equipment. The granulation mainly relies on the bridging action of the binder to cause the powders to be entangled with each other. By boiling granulation, improving fluidity and reducing dust flying are beneficial to the implementation of GMP.
Fourth, drying equipment:
1. Hot air circulation oven: using steam and electricity as heat source, heating by heater, a large amount of hot air is circulating in the hot air in the box, fresh air is continuously replenished into the tank from the air inlet, and then continuously discharged from the moisture exhaust port, which increases the heat transfer effect. , so that the moisture in the material in the box is gradually reduced; if the far-infrared quartz tube is used as the heating element, the thermal efficiency is high and the sanitary condition is good.
2, to use GMP oven: the heat source has three ways of steam, electricity, electricity and steam, the temperature can be automatically controlled, there are recorder records. The air inlet is matched with the gas filter, and the moisture outlet is equipped with a medium efficiency filter.
Fifth, tableting equipment:
1. Single punching machine: The machine is equipped with a pair of die, Zui large from 12mn diameter, Zui large filling depth of 11mm, production capacity of 80-100 pieces / min, suitable for laboratory trial production or small batch production.
2, rotary tablet press: according to the number of holes on the turntable is divided into 19 punch, 21 punch, 27 punch, 33 punch, 37 punch, 55 punch, 75 punch, the capacity is up to 5600 pieces / min. At present, most of the pharmaceutical companies use a rotary tablet press with electromechanical integration, high-speed, full-process control, and automatic chipping.
3, high-speed tablet press: controlled by computer, the use of double pressure, sealing operation, the film is superior to ordinary tablet press in all aspects, can guarantee product quality.
Sixth, the coating machine:
The core of the core is continuously traversed in the rotating drum of the coating machine, and the coating liquid is sprayed from the inlet spray gun to the surface of the core. At the same time, under the action of exhaust and negative pressure, the 100000-level clean hot air supplied by the hot air cabinet is discharged from the damper through the core, and the coating medium is quickly and uniformly dried on the surface of the core to form a firm, dense and smooth surface film. The entire process is done automatically under program control. The flow rate between the guns is uniform and uniform, and air atomization is adopted, and the atomization particle size is uniform.
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