Nicotine and alcohol addiction mechanisms are revealed
January 14, 2019 Source: Health News Author: Sun Guo Xiao warm root
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Under the support of several funds such as the National Natural Science Foundation and Shanghai Major Projects, Prof. Feng Jianfeng, Dean of the Institute of Brain Intelligence Science and Technology of Fudan University, led international cooperation with researchers from Warwick University, Oxford University and Cambridge University. The team conducted brain network modeling analysis on nearly 2,000 subjects, and after two years of research, finally found and found a neural circuit closely related to smoking and drinking. In the long-term smoking group, the synchrony between the brain regions of the subjects was significantly reduced; in the long-term drinking group, the synchrony between the brain regions of the subjects was significantly increased. The increase or decrease in synchrony abnormalities affects the function of the human brain. This finding lays a theoretical foundation for revealing the mechanism of action of nicotine and alcohol on the brain, and is of great significance to the global public health problem of tobacco and alcohol addiction and the development of specific treatment methods for tobacco and alcohol addiction. Related research papers were published online in the biomedical academic journal "e Life" on January 8th and were selected as special reports of "E-Life Digest".
It is reported that Feng Jianfeng's research team integrated the American Brain Connection Group Program and the European Youth Data Two Brain Image Database and found that the brain function connectivity of the smokers showed an overall weakening trend, mainly involving the lateral orbitofrontal cortex of the brain area; The brain function connections showed an overall trend of enhancement, mainly involving the medial orbitofrontal cortex of the brain region, that is, in the long-term smoking group, the abnormal brain regions of the subjects were mainly concentrated in the punishment (non-reward) function-related lateral hernia. In the long-term drinking group, the abnormal brain area is mainly concentrated in the medial orbitofrontal cortex associated with the reward function, while the lateral orbitofrontal cortex of the human brain is mainly responsible for negative stimulation such as punishment (non-reward), and the medial orbitofrontal cortex is mainly responsible. Positive incentives such as rewards. The study found that the smoking group's sensitivity to brain punishment was reduced, while the drinking group's sensitivity to brain reward function increased. Whether it is desensitizing to punishment or being too excited about rewards can lead to people's dependence on certain substances. This also explains the dependence of long-term smoking and drinking people on nicotine and alcohol. The study also found that these brain connections associated with smoking and drinking were significantly associated with smoking, alcohol consumption, and impulsive behavior.
The research team found that even a small amount of smoking and drinking can cause abnormal brain connections, which in turn affects the cognitive function of the human brain. Feng Jianfeng said that this is consistent with the results of a large-scale drinking survey conducted on the Lancet not long ago. This once again reminds the public that the traditional view of small smoke and small wine does not hurt the body is wrong.
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